Uploaded on 1 August , 2012
Length : 6:08
Category: Case Studies.
Calprotectin is the best marker to discriminate between organic (IBD) and non-organic bowel disease (IBS). Calprotectin is a reliable indicator of inflammation in several pathologies. Patients suffering from IBS do not have increased faecal calprotectin values. Faecal calprotectin concentrations, as measured by the Bühlmann Calprotectin assays, are significantly elevated in patients with IBD and correlate well with endoscopic and histological assessment of disease activity.
Around 2 million people in Europe suffer from IBD. Morbus Crohn and Colitis ulcerosa are incurable serious chronic diseases of the intestinal tract. The symptoms are distressing, embarrassing and even debilitating. Once symptoms appear, they resemble those of other conditions of functional origin (IBS), which make it very difficult for doctors to correctly diagnose. IBS is often confused with ulcerative colitis and Crohn’s disease. The inflammation typical of these diseases is not present in IBS. It is assumed that IBS affects over 30 million people in Europe and results in over 2 million yearly visits to physicians. Twenty to 30 percent of all visits to gastro enterologists are due to symptoms of IBS. Calprotectin is a clear gatekeeper marker enabling the clinician to decide whether a patient should be referred for colonoscopy or to treat them for IBS symptoms.
The clinical course of most patients with IBD is marked by periods of remission with intermittent relapses characterized by increased intestinal inflammation. Numerous published studies, by Tibble et al. and others, have studied the levels of calprotectin in patients during the course of the disease. The results show that calprotectin is a good predictor of relapse in patients with IBD, thus giving clinicians an effective tool to adapt the patients treatment accordingly and to ease the relapse severity.